Chimie analytique des molécules bioactives et pharmacognosie – CAMBAP

Les recherches menées par l’équipe CambaP portent sur la recherche, l’analyse et l’identification de molécules bioactives. Pour cela, les sujets de recherches portés par l’équipe visent, le plus souvent, à développer des méthodes innovantes d’extraction et d’analyse ou à concevoir des systèmes analytiques permettant l’étude de ces molécules bioactives. Il s’agit essentiellement de molécules ayant ou supposées avoir un intérêt thérapeutique ou fonctionnel (vitamines, polyphénols, terpènes, bactériocines, alcaloïdes, lipides…) issues de différentes matrices telles que des plantes, des aliments, des formulations médicamenteuses ou cosmétiques, des champignons ou des microorganismes…Les membres de l’équipe sont spécialisés en chimie analytique, en pharmacognosie, et en culture cellulaire animale, microbienne et végétale.

Responsable scientifique : Saïd ENNAHAR

Membres de l’équipe CAMBAP


Martine BERGAENTZLE

Chercheur-CDD
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Said ENNAHAR

Chercheur
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Patrick GUTERL

ITA
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Diane JULIEN DAVID

Chercheur
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Sonia LORDEL

Chercheur
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Eric MARCHIONI

Chercheur
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Christophe MARCIC

Chercheur
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Aurélie URBAIN

Chercheur
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Ludivine VALOIS

Chercheur
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Publications récentes

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Chamandy A.; Zhao, M.; Rammal, H.; Ennahar, E.
Hyphenated LC-ABTS¥+ and LC-DAD-HRMS for simultaenous analysis and identification of antioxidant compounds in Astragalus emarginatus Labill. extracts.
Journal of Pharmaceutical Analysis , 2021, , . (10.1016/j.jpha.2021.09.008    ).

Triaux, Zélie; Briard, Léa; Petit, Odile; Marchioni, Eric; Julien-David, Diane
Effect of simulated foregut digestion on the antioxidant capacity of plants naturally consumed by horses
Animal Feed Science and Technology, 2021, 282, 115121. (10.1016/j.anifeedsci.2021.115121).

Balde, M.; Urbain, A.; Diédhiou, A.; Gueye, S.; Dior Fall, A.; Wélé, A.; Marchioni, E.; Julien-David, D.
Phytochemical characterization and free radical scavenging capacity of aqueous and ethanolic extracts of Parinari macrophylla Sabine (Chrysobalanaceae)
Asian Journal of Research in Chemistry and Pharmaceutical Sciences, 2021, 9, 01-08. (10.36673/AJRCPS.2021.v09.i01.A52     ).

Zhou, L.; Yang, F.; Zhao, M. J.; Zhang, M. H.; Liu, J. K.; Marchioni, E.
Determination and comparison of phospholipid profiles in eggs from seven different species using UHPLC-ESI-Triple TOF-MS
Food Chemistry, 2021, 339, 127856. (10.1016/j.foodchem.2020.127856).

Gosset-Erard, C.; Zhao, M. J.; Lordel-Madeleine, S.; Ennahar, S.
Identification of punicalagin as the bioactive compound behind the antimicrobial activity of pomegranate (Punica granatum L.) peels
Food Chemistry, 2021, 352, . (10.1016/j.foodchem.2021.129396).

Yang, F.; Zhao, M.; Zhou, L.; Zhang, M.; Liu, J.; Marchioni E.
Identification and differentiation of wide edible mushrooms based on lipidomics profiling combined with principal component analysis
Journal of Agricultural and Food Chemistry, 2021, 69(34), 9991Ð10001. (10.1021/acs.jafc.1c02269).

Triaux, Z.; Petitjean, H.; Marchioni, E.; Steyer, D.; Marcic, C.
Comparison of Headspace, Hydrodistillation and Pressurized Liquid Extraction of Terpenes and Terpenoids from Food Matrices-Qualitative and Quantitative Analysis
Journal of Analytical Chemistry, 2021, 76(3), 284-295. (10.1134/s1061934821030151).

Huguet, Clément; Real, Eleonore; Zhao, Wei-Min; Urbain, Aurélie
Secretion of glucagon-like peptide-1 induced by Cynanchum pregnane derivatives: preliminary hypotheses regarding key structural elements
Phytochemistry Letters, 2021, 41, 88-91. (10.1016/j.phytol.2020.11.008).

Hamers, Violette; Huguet, Clément; Bourjot, Mélanie; Urbain, Aurélie
Antibacterial compounds from mushrooms: a lead to fight ESKAPEE pathogenic bacteria?
Planta Medica, 2021, 87, 351-367. (10.1055/a-1266-6980).

Favre-Godal Q.; Schwob P.; Lecoultre N.; Hofstetter V.; Gourguillon L.; Riffault-Valois L.; Lordel-Madeleine S.; Gindro K.; Choisy P.
Fungal community of Dendrobium fimbriatum (Orchidaceae): Selection of the most probable interacting fungi and their molecular compositions.
Planta Medica, 2021, 87(15), 1281-1282. (10.1055/s-0041-1736885).

Favre-Godal Q.; Schwob P.; Lecoultre N.; Hofstetter V.; Gourguillon L.; Riffault-Valois L.; Lordel-Madeleine S.; Gindro K.; Choisy P.
Plant-microbe features of Dendrobium fimbriatum (Orchidaceae) fungal community.
Symbiosis, 2021, 85(1), 31Ð46. (10.1007/s13199-021-00786-0).

Adjali, A.; Clarot, I.; Chen, Z.; Marchioni, E.; Boudier, A.
Physicochemical degradation of phycocyanin and means to improve its stability: A short review.
Journal of Pharmaceutical Analysis , 2021, , . (10.1016/j.jpha.2021.12.005).

Radajewska, A.; Przybyszewski, O.; Emhemmed, F.; Muller, C. D.; Barg, E.; Moreira, H.
Three dimensional in vitro culture systems in anticancer drug discovery targeted on cancer stem cells
American Journal of Cancer Research, 2021, 11(10), 4931-4946. ().

Pleger, L.; Weindl, P.N.; Weindl, P.A.; Carrasco, L.S.; Leitao, C.; Zhao, M.; Aulrich, K. Bellof, G.
Precaecal digestibility of crude protein and amino acids of alfalfa (Medicago sativa) and red clover (Trifolium pratense) leaves and silages in broilers.
Animal Feed Science and Technology, 2021, 275, 114856. (10.1016/j.anifeedsci.2021.114856).

Awan S.; Lambert M.; Imtiaz A.; Alpy F.; Tomasetto, M.; OuladAbdelghani A.; Schaeffer C.; Moritz C.; Julien-David D.; Najib S.; Martinez L. O.; Matz R. L.; Collet X.; Silva-Rojas R.; Böhm J.; Herz J.; Terrand J.; Boucher P.
Wnt5a Promotes Lysosomal Cholesterol Egress and Protects Against Atherosclerosis
Circulation Research, 2021, 130(2), 184-199. (10.1161/CIRCRESAHA.121.318881 ).

Charlet, A.; Hilfiger, L.; Triaux, Z.; Marcic, C.; Emhemmed, F.; Darbon, P.; Marchioni, E.; Petitjean, H.
Anti-hyperalgesic Properties of Menthol and Pulegone
Frontiers in Pharmacology, 2021, 12, 753873. (10.3389/fphar.2021.753873).

Ahmad, T.; Ashraf, W.; Ibrahim, A.; Zaayter, L.; Muller, C. D.; Hamiche, A.; Mely, Y.; Bronner, C.; Mousli, M.
TIP60 governs the autoubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex
International Journal of Oncology, 2021, 59(5), . (10.3892/ijo.2021.5269).

Terfassi, S.; Dauvergne, X.; Cerantola, S.; Lemoine, C.; Bensouici, C.; Fadila, B.; Christian, M.; Marchioni, E.; Benayache, S.
First report on phytochemical investigation, antioxidant and antidiabetic activities of Helianthemum getulum
Natural Product Research, 2021, , 1-8. (10.1080/14786419.2021.1928664).

Esseid, C.; Leon, F.; Mosset, P.; Benayache, S.; Marchioni, E.; Brouard, I.; Benayache, F.
Coumarins and other constituents from Deverra battandieri
Phytochemistry Letters, 2021, 42, 129-133. (10.1016/j.phytol.2020.08.013).

Abid F.; Saleem M.; Muller C.D.; Asim S.H.; Arshad S.; Maqbool T.; Hadi F.
Anti_Proliferative and Apoptosis_Inducing Activity of Acacia Modesta and Opuntia Monocantha Extracts on HeLa Cells.
Asian Pacific Journal of Cancer Prevention, 2020, 21(10), 3125_3131. (10.31557/APJCP.2020.21.10.3125).

Triaux, Zélie; Petitjean, Hugues; Marchioni, Eric; Boltoeva, Maria; Marcic, Christophe
Deep eutectic solventÐbased headspace single-drop microextraction for the quantification of terpenes in spices
Analytical and Bioanalytical Chemistry, 2020, 412(4), 933-948. (10.1007/s00216-019-02317-9).

Matsuo, Y.; Miura, L. A.; Araki, T.; Riffault-Valois, L.; Yoshie-Stark, Y.
Comparison of Antioxidant Properties of Different Crude Extracts from Citrus natsudaidai Peel
Food Science and Technology Research, 2020, 26(6), 837-846. (10.3136/fstr.26.837).

Yuan, Y.; Zhao, M. J.; Riffault-Valois, L.; Ennahar, S; Bergaentzle, M.; Marchioni, Eric
Online acetylcholinesterase inhibition evaluation by high-performance liquid chromatography-mass spectrometry hyphenated with an immobilized enzyme reactor
Journal of Chromatography A, 2020, 1609, 460506. (10.1016/j.chroma.2019.460506).

Yang, F.; Zhou, L.; Zhang, M. H.; Liu, J. K.; Marchioni, E.
Exploration of natural phosphatidylcholine sources from six beans by UHPLC-Q-HRMS
Journal of Food Science, 2020, 85, 3202-3213. (10.1111/1750-3841.15393).

Ben Ayache, S.; Saafi, E. B.; Emhemmed, F.; Flamini, G.; Achour, L.; Muller, C. D.
Biological Activities of Aqueous Extracts from Carob Plant (Ceratonia siliquaL.) by Antioxidant, Analgesic and Proapoptotic Properties Evaluation
Molecules, 2020, 25(14), 3120. (10.3390/molecules25143120     ).

Favre-Godal, Q.; Gourguillon, L.; Lordel-Madeleine, S.; Gindro, K.; Choisy, P.
Orchids and their mycorrhizal fungi: an insufficiently explored relationship
Mycorrhiza, 2020, 30(1), 44682. (10.1007/s00572-020-00934-2).

Belaouira, R.; Marchioni, E.; Benayache, F.; Benayache, S.
On-line screening and identification of polyphenolic antioxidant compounds of Convolvulus trabutianus
Natural Product Research, 2020, 34(10), 1490-1493. (10.1080/14786419.2018.1510398 ).

Favre-Godal Q.; Hubert J.; Kotland A.; Beaugendre C.; Gourguillon L.; Urbain A.; Lordel-Madeleine S.; Choisy P. Planta Med 87(15): .
Phytochemical assessment of Dendrobium fimbriatum Hook (Orchidaceae).
Planta Medica, 2020, 87(15), 1272. (10.1007/978-981-32-9456-1_28).

Thihara Rodrigues, Flavio; Marchioni, Eric; Lordel-Madeleine, Sonia; Kuntz, Florent; Casañas Haasis Villavicencio, Anna Lucia; Julien-David, Diane
Degradation of profenofos in aqueous solution and in vegetable sample by electron beam radiation
Radiation Physics and Chemistry, 2020, 166, 108441. (10.1016/j.radphyschem.2019.108441).

Filipovi_, N. R.; Bjelogrli_, Sne_ana K.; Pelliccia, Sveva; Jovanovi_, Vesna B.; Koji_, Milan; Sen_anski, Milan; La Regina, Giuseppe; Silvestri, Romano; Muller, C. D.; Todorovi_, Tamara R.
Selenotriapine – An isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors
Arabian Journal of Chemistry, 2020, 13(1), 1466-1489. (10.1016/j.arabjc.2017.11.017).

Dieng, S. M.; Omran, Z.; Anton, N.; Thioune, O.; Djiboune, A. R.; Sy, P. M.; Messaddeq, N.; Ennahar, S.; Diarra, M.; Vandamme, T.
Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for poorly soluble drugs
Colloids and Surfaces B-Biointerfaces, 2020, 191, 111010. (10.1016/j.colsurfb.2020.111010).

Djiboune A.R.; Anton N.; Dieng S.M.; Sy P.M.; Diouf L.A.D.; Mbaye G.; Soumboundou M.; Messaddeq N.; Ennahar S.; Vandamme T.F.; Diarra M.
pH-thermosensitive oral hydrogels containing phenobarbital for a potiential pediatric use
European Journal of Biophysics, 2020, 8, 43Ð51. (10.11648/j.ejb.20200802.15).

Pleger, L.; Weindl, P. N.; Weindl, P.; A.; Carrasco.; L. S.; Leitao, C.; Zhao, M.; Aulrich, K. Bellof, G.
Effects of increasing alfalfa (Medicago sativa) leaf levels on the fattening and slaughtering performance of organic broilers (JAPAN-Sep-19-731)
Journal of Animal Physiology, 2020, 104(5), 1317-1332. (10.1111/jpn.13353).

Attia, R.; Zedet, A.; Bourjot, M.; Skhiri, E.; Messaoud, C.; Girard, C.
Thin-layer chromatography-bioautographic method for the detection of arginase inhibitors.
Journal of Separation Science, 2020, 43(12), 2477Ð2486. (10.1002/jssc.201901210).

Brignier, N.; Leitao, C.; Steyer, D.; Heitz, F.; Wuchner, A.; Laugel, B.; Marcic, C.
Barbe rouge: impact of hopping method on sensory and analytical properties of beers
BRAUWELT International, 2019, 5, 330-335. ().

Triaux, Z.; Petitjean, H.; Marchioni, E.; Steyer, D.; Marcic, C.
Optimization by experimental design of headspace sorptive extraction and solid-phase microextraction for the determination of terpenes in spices
Food Analytical Methods, 2019, 12(12), 2764-2776. (10.1007/s12161-019-01622-4).

Lajili, S.; Ammar, H. H.; Mzoughi, Z.; Amor, H. B. H.; Muller, Christian D.; Majdoub, H.; Bouraoui, A.
Characterization of sulfated polysaccharide from Laurencia obtusa and its apoptotic, gastroprotective and antioxidant activities
International Journal of Biological Macromolecules, 2019, 126, 326-336. (10.1016/j.ijbiomac.2018.12.089).

Abdelhamid, A.; Lajili, S.; Elkaibi, M. A.; Ben Salem, Y.; Abdelhamid, A.; Muller, Christian D.; Majdoub, H.; Kraiem, J.; Bouraoui, A.
Optimized Extraction, Preliminary Characterization and Evaluation of the in Vitro Anticancer Activity of Phlorotannin-Rich Fraction from the Brown Seaweed, Cystoseira sedoides
Journal of Aquatic Food Product Technology, 2019, 28(9), 892-909. (10.1080/10498850.2019.1662865).

Zhao, M. J.; Bergaentzle, M.; Flieller, A.; Marchioni, Eric
Development and validation of an ultra-high performance liquid chromatography-high resolution mass spectrometry method for simultaneous quantification of cyanogenic glycosides and secoisolariciresinol diglucoside in flaxseed (Linum usitatissimum L.)
Journal of Chromatography A, 2019, 1601, 214-223. (10.1016/j.chroma.2019.04.072).

Hammi, I.; Amensag, Kamar; Ennahar, S.; Delalande, F.; Marchioni, E.; Cianferani, S.; Belkhou, R.
Native production of pediocin PA-1 by Enterococcus faecium E16 isolated from goats’ cheese
Journal of Food and Nutrition Research, 2019, 58, 44774. ().

Huguet, Clément; Olatunji, O. J.; Real, E.; Raharivelomanana, P.; Urbain, Aurélie
Glucagon-like peptide-1 secretagogues from the leaves of Oparanthus teikiteetinii
Phytochemistry Letters, 2019, 30, 201-204. (10.1016/j.phytol.2019.02.020).

Favre-Godal, Q.; Gourguillon, L.; Riffault-Valois, L.; Urbain, A.; Lordel-Madeleine, S.; Gindro, K.; Choisy, P.
Orchids and their mycorrhizal fungi: an insufficiently explored relationship
Planta Medica, 2019, 85(18), 1445-1445. (10.1055/s-0039-3399784).

Favre-Godal, Q.; Gourguillon, L.; Riffault-Valois, L.; Urbain, A.; Lordel-Madeleine, S.; Choisy, P.
LC-MS/MS and molecular networking: a complementary approach for chemical composition evaluation of plant extracts – case study with Orchidaceae species
Planta Medica, 2019, 85(18), 1464-1464. (10.1055/s-0039-3399836).

Amensag, Kamar; Ennahar, Saïd; Akhtach, Sihame; Guessous, Mohamed; Belkhou, Rajae
Enhanced killing of multiresistant strains of Staphylococcus aureus and Acinetobacter baumannii through a combined action of antibiotics and bacteriocins
South Asian Journal of Experimental Biology, 2019, 9, . ().

Emhemmed, F.; Azouaou, S. A.; Hassan, S.; Lefevbre, R.; Desaubry, L.; Muller, Christian D.; Fuhrmann, G.
The synthetic flavagline FL3 spares normal human skin cells from its cytotoxic effect via an activation of Bad
Toxicology in Vitro, 2019, 60, 27-35. (10.1016/j.tiv.2019.04.025).

Riffault-Valois, L.; Wattez, C.; Langrand, J.; Boucaud-Maitre, D.; Gaslonde, T.; Colas, C.; Nossin, E.; Blateau, A.; Michel, S.; Cachet, X.
Health risk associated with the oral consumption of « Chiniy-tref », a traditional medicinal preparation used in Martinique (French West Indies): Qualitative and quantitative analyses of aristolochic acids contained therein.
Toxicon, 2019, 172, 53Ð60. (10.1016/j.toxicon.2019.10.241).

Ory, L.; Nazih, E. H.; Daoud, S.; Mocquard, J.; Bourjot, M.; Margueritte, L.; Delsuc, M. A.; Bard, J. M.; Pouchus, Y. F.; Bertrand, S. Roullier, C.
Targeting bioactive compounds in natural extracts – Development of a comprehensive workflow combining chemical and biological data
Analytica Chimica Acta, 2019, 1070, 29-42. (10.1016/j.aca.2019.04.038).

Beurton, J.; Clarot, I.; Stein, J.; Creusot, B.; Marcic, C.; Marchioni, E.; Boudier, A.
Long-lasting and controlled antioxidant property of immobilized gold nanoparticles for intelligent packaging
Colloids and Surfaces B-Biointerfaces, 2019, 176, 439-448. (10.1016/j.colsurfb.2019.01.030).

Margueritte, L.; Duciel, L.; Bourjot, M.; Vonthron-Senecheau, C.; Delsuc, M.-A.
Automatised pharmacophoric deconvolution of plant extracts – application to Cinchona bark crude extract
Faraday Discussions, 2019, 218, 441Ð458. (10.1039/c8fd00242h).

Petitgonnet C.; Klein G. L.; Roullier-Gall C.; Schmitt-Kopplinb P.; Vichi S.; Julien-David D.; Alexandre H.
Influence of cell-cell contact on yeast interactions and exo-metabolome
Food Microbiology, 2019, 83, 122-133. (10.1016/J.FM.2019.05.005).

Bjelogrlic, S.; Todorovic, T. R.; Cvijetic, I.; Rodic, M. V.; Vujcic, M.; Markovic, S.; Araskov, J.; Janovic, B.; Emhemmed, F.; Muller, C. D.; Filipovic, N. R.
A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells
Journal of Inorganic Biochemistry, 2019, 190, 45-66. (10.1016/j.jinorgbio.2018.10.002      ).

Bjelogrlic, S. K.; Todorovic, T. R.; Kojic, M.; Sencanski, M.; Nikolic, M.; Visnjevac, A.; Araskov, J.; Miljkovic, M.; Muller, Christian D.; Filipovic, N. R.
Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification
Journal of Inorganic Biochemistry, 2019, 199, UNSP110758. (10.1016/j.jinorgbio.2019.110758      ).

Note, O. P.; Simo, L. M.; Mbing, J. N.; Guillaume, D.; Muller, Christian D.; Pegnyemb, D. E.; Lobstein, A.
Structural determination of two new acacic acid-type saponins from the stem barks of Albizia zygia (DC.) J. F. Macbr
Natural Product Research, 2019, 33(2), 180-188. (10.1080/14786419.2018.1440228).

Gervason, S.; Larkem, D.; Ben Mansour, A.; Botzanowski, T.; Muller, C. S.; Pecqueur, L.; Le Pavec, G.; Delaunay-Moisan, A.; Brun, O.; Agramunt, J.; Grandas, A.; Fontecave, M.; Schunmann, V.; Cianférani, Sarah; Sizun, C.; Toledano, M. B.; D’Autreaux, B.
Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin
Nature Communications, 2019, 10, 3566. (10.1038/s41467-019-11470-9).

Dieng, S. M.; Anton, N.; Bouriat, P.; Thioune, O.; Sy, P. M.; Massaddeq, N.; Ennahar, S.; Diarra, M.; Vandamme, T.
Pickering nano-emulsions stabilized by solid lipid nanoparticles as a temperature sensitive drug delivery system
Soft Matter, 2019, 15(40), 8164-8174. (10.1039/c9sm01283d).

Boucaud-Maitre, Denis; Cachet, Xavier; Bouzidi, Chouaha; Riffault-Valois, Ludivine; Dupuy, Carolin; Gamier, Robert; Langrand, Jérôme
Severity of manchineel fruit (Hippomane mancinella) poisoning: A retrospective case series of 97 patients from French Poison Control Centers
Toxicon, 2019, 161, 28-32. (10.1016/j.toxicon.2019.02.014 ).

Van der Werf, R.; Walter, C.; Bietiger, W.; Seyfritz, E.; Mura, C.; Peronet, C.; Legrandois, J.; Werner, D.; Ennahar, S.; Digel, F.; Maillard-Pedracini, E.; Pinget, M.; Jeandidier, N.; Marchioni, E.; Sigrist, S.; Dal, S.
Beneficial effects of cherry consumption as a dietary intervention for metabolic, hepatic and vascular complications in type 2 diabetic rats
Cardiovascular Diabetology, 2018, 17, 20. (10.1186/s12933-018-0744-6).

Balde, Mamadou; Ennahar, Said; Dal, Stephanie; Sigrist, Severine; Wele, Alassane; Marchioni, Eric; Julien-David, Diane
Influence of the physicochemical parameters of solvents in the extraction of bioactive compounds from Parinari macrophylla Sabine (Chrysobalanaceae)
European Journal of Chemistry, 2018, 9(3), 161-167. (10.5155/eurjchem.9.3.161-167.1723    ).

Note, O. P.; Kamto, E. L. D.; Toukea, D. D.; Aouazou, S. A.; Mbing, J. N.; Muller, C. D.; Guillaume, D.; Pegnyemb, D. E.
Pro-apoptotic activity of new triterpenoid saponins from the roots of Albizia adianthifolia (Schumach.) W.Wight.
Fitoterapia, 2018, 129, 34Ð41. (10.1016/j.fitote.2018.06.008).

Czuba, E.; Diop, M.; Mura, C.; Schaschkow, A.; Langlois, A.; Bietiger, W.; Neidl, R.; Virciglio, A.; Auberval, N.; Julien-David, D.; Maillard, E.; Frere, Y.; Marchioni, E.; Pinget, M.; Sigrist, S.
Oral insulin delivery, the challenge to increase insulin bioavailability: Influence of surface charge in nanoparticle system
International Journal of Pharmaceutics, 2018, 542(1-2), 47-55. (10.1016/j.ijpharm.2018.02.045).

Czuba, E.; Julien-David, D.; Engel, T.; Pinget, M.; Sigrist, S.; Marchioni, E.; Bergaentzle, M.
Validation of a major modification of the mobile phase in the European Pharmacopoeia LC-UV human insulin assay
Journal of Liquid Chromatography & Related Technologies, 2018, 41(12), 804-809. (10.1080/10826076.2018.1514510).

Nardella, F.; Margueritte, L.; Lamure, B.; Vieville, J. M. P.; Bourjot, M.
Targeted discovery of bioactive natural products using a pharmacophoric deconvolution strategy: Proof of principle with eleganolone from Bifurcaria bifurcata R. Ross.
Phytochemistry Letters, 2018, 26, 138Ð142. (10.1016/j.phytol.2018.05.034).

Gourguillon, L.; Rustenholz, C.; Lobstein, A.; Gondet, L.
Callus induction and establishment of cell suspension cultures of the halophyte Armeria maritima (Mill.) Willd.
Scientia Horticulturae, 2018, 233, 407-411. (10.1016/j.scienta.2017.08.001).

Brignier, N.; Steyer, D.; Clayeux, C.; Marcic, C.; Heitz, F.; Wuchner, A.; Laugel, B.
Effect of Hop Varieties Aramis, Mistral and Barbe Rouge on Beer Aroma During Dry Hopping
BRAUWELT International, 2018, 3, 200-205. ().

Montoro, B. P.; Benomar, N.; Gomez, N. C.; Ennahar, S.; Horvatovich, P.; Knapp, C. W.; Galvez, A.; Abriouel, H.
Proteomic analysis of Lactobacillus pentosus for the identification of potential markers involved in acid resistance and their influence on other probiotic features
Food Microbiology, 2018, 72, 31-38. (10.1016/j.fm.2017.11.006).

Montoro, B. P.; Benomar, N.; Gomez, N. C.; Ennahar, S.; Horvatovich, P.; Knapp, C. W.; Alonso, E.; Galvez, A.; Abriouel, H.
Proteomic analysis of Lactobacillus pentosus for the identification of potential markers of adhesion and other probiotic features
Food Research International, 2018, 111, 58-66. (10.1016/j.foodres.2018.04.072).

Sy, P. M.; Anton, N.; Idoux-Gillet, Y.; Dieng, S. M.; Messaddeq, N.; Ennahar, S.; Diarra, M.; Vandamme, T. F.
Pickering nano-emulsion as a nanocarrier for pH-triggered drug release
International Journal of Pharmaceutics, 2018, 549(1-2), 299-305. (10.1016/j.ijpharm.2018.07.066).

Margueritte, L.; Markov, P.; Chiron, L.; Starck, J.-P.; Vonthron-Senecheau, C.; Bourjot, M.; Delsuc, M.-A.
Automatic differential analysis of NMR experiments in complex samples
Magnetic Resonance in Chemistry, 2018, 56(6), 469Ð479. (10.1002/mrc.4683).

de Vera, C. R.; Crespin, G. D.; Daranas, A. H.; Looga, S. M.; Lillsunde, K. E.; Tammela, P.; Perala, M.; Hongisto, V.; Virtanen, J.; Rischer, H.; Muller, C. D.; Norte, M.; Fernandez, J. J.; Souto, M. L.
Marine Microalgae: Promising Source for New Bioactive Compounds
Marine Drugs, 2018, 16(9), 317. (10.3390/md16090317).

Dovgan, I.; Erb, S.; Hessmann, S.; Ursuegui, S.; Michel, C.; Muller, C.; Chaubet, G.; Cianférani, S.; Wagner, A.
Arginine-selective bioconjugation with 4-azidophenyl glyoxal: application to the single and dual functionalisation of native antibodies
Organic & Biomolecular Chemistry, 2018, 16(8), 1305-1311. (10.1039/c7ob02844j).

Dal, S.; Van der Werf, R.; Walter, C.; Bietiger, W.; Seyfritz, E.; Mura, C.; Peronet, C.; Legrandois, J.; Werner, D.; Ennahar, S.; Digel, F.; Elisa, M. P.; Pinget, M.; Jeandidier, N.; Marchioni, E.; Sigrist, S.
Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats
Oxidative Medicine and Cellular Longevity, 2018, , 7019573. (10.1155/2018/7019573).

Emhemmed, F.; Azouaou, S. A.; Zhao, Q.; Appert-Collin, A.; Bennasroune, A.; Schini-Kerth, V. B.; Muller, C. D.; Desaubry, L.; Fuhrmann, G.
Pro-differentiating effects of a synthetic flavagline on human teratocarcinomal cancer stem-like cells
Cell Biology and Toxicology, 2017, 33(3), 295-306. (10.1007/s10565-016-9375-4).

Simo, L. M.; Note, O. P.; Mbing, J. N.; Aouazou, S. A.; Guillaume, D.; Muller, C. D.; Pegnyemb, D. E.; Lobstein, A.
New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera (J.F GMEL.) CASM
Chemistry & Biodiversity, 2017, 14(10), e1700260. (10.1002/cbdv.201700260).

Clayeux, C.; Marchioni, E.; Van der Werf, R.; Dal, S.; Sigrist, S.; Steyer, D.; Ennahar, S.
Compared Chemical Activity and Effects on Cell Viability of Various Antioxidant Compounds
Current Analytical Chemistry, 2017, 13(2), 104-110. (10.2174/1573411012666160213002321).

Auberon, F.; Olatunji, O. J.; Raminoson, D.; Muller, Christian D.; Soengas, B.; Bonte, F.; Lobstein, A.
Isolation of novel stilbenoids from the roots of Cyrtopodium paniculatum (Orchidaceae)
Fitoterapia, 2017, 116, 99-105. (10.1016/j.fitote.2016.11.015  ).

Cambrai, A.; Marchioni, E.; Julien-David, D.; Marcic, C.
Discrimination of Cocoa Bean Origin by Chocolate Polyphenol Chromatographic Analysis and Chemometrics
Food Analytical Methods, 2017, 10(6), 1991-2000. (10.1007/s12161-016-0744-7     ).

Le Grandois, J.; Guffond, D.; Hamon, E.; Marchioni, E.; Werner, D.
Combined microplate-ABTS and HPLC-ABTS analysis of tomato and pepper extracts reveals synergetic and antagonist effects of their lipophilic antioxidative components
Food Chemistry, 2017, 223, 62-71. (10.1016/j.foodchem.2016.12.008).

Lajili, S.; Deghrigue, M.; Abdelhamid, A.; Bjelogrli_, S.; Muller, C. D.; D’auria, V.; Bouraoui, A.
Anticancer activity of diterpenes and steroids from Eunicella singularis against two-and three-dimensional breast cancer cell models
Journal of Coastal Life Medicine, 2017, 5 (12) , 531-539. (10.12980/jclm.5.2017J7-155).

Chemam, Y.; Benayache, S.; Marchioni, E.; Zhao, M.; Mosset, P.; Benayache, F.
On-Line Screening, Isolation and Identification of Antioxidant Compounds of Helianthemum ruficomum
Molecules, 2017, 22, 239. (10.3390/molecules22020239).

Note, O. P.; Messi, L. M.; Mbing, J. N.; Azouaou, S. A.; Sarr, M.; Guillaume, D.; Muller, Christian D.; Pegnyemb, D. E.; Lobstein, A.
Pro-apoptotic activity of acylated triterpenoid saponins from the stem bark of Albizia chevalieri harms
Phytochemistry Letters, 2017, 22, 95-101. (10.1016/j.phytol.2017.09.008).

Tsoukalas, Michail, Psichas, A.; Reimann, F.; Gribble, F. M.; Lobstein, A.; Urbain, A.
Pregnane glycosides from Cynanchum menarandrense
Steroids,, 2017, 125, 27Ð32. (10.1016/j.steroids.2017.06.005).

Hagemann, M.H.; Schmidt-Cotta, V.; Marchioni, E.; Braun, S.
Chance for Dry-hopped Non-alcoholic Beverages? Part 2: Health Properties and Target Consumers
BrewingScience, 2017, 70, 118. (10.23763/BrSc17-10Hagemann).

Kolodych, S.; Michel, C.; Delacroix, S.; Koniev, O.; Ehkirch, A.; Eberova, J.; Cianférani, S.; Renoux, B.; Krezel, W.; Poinot, P.; Muller, C. D.; Papot, S.; Wagner, A.
Development and evaluation of beta-galactosidase-sensitive antibody-drug conjugates
European Journal of Medicinal Chemistry, 2017, 142, 376-382. (10.1016/j.ejmech.2017.08.008).

Gorecki, S.; Bemrah, N.; Roudot, A. C.; Marchioni, E.; Le Bizec, B.; Faivre, F.; Kadawathagedara, M.; Botton, J.; Riviere, G.; Eden Mother-Child Cohort Study Group,
Human health risks related to the consumption of foodstuffs of animal origin contaminated by bisphenol A
Food and Chemical Toxicology, 2017, 110, 333-339. (10.1016/j.fct.2017.10.045).

Lechevretel, Ludivine; Santucci, R.; Burgin-Noll, M.; Caille, C.; Marchioni, E.; Pieri, F.; Jourdil, A.; Couturier, F.; Challan-Belval, P.
Effect of Vitamin E on the Anti-Coagulant Response
Global Journal of Pharmacy & Pharmaceutical Sciences, 2017, 1(3), 555563. (10.19080/gjpps.2017.01.555563).

Jimenez-Quero, A.; Pollet, E.; Zhao, M.; Marchioni, Eric; Averous, L.; Phalip, V.
Fungal Fermentation of Lignocellulosic Biomass for Itaconic and Fumaric Acid Production
Journal of Microbiology and Biotechnology, 2017, 27(1), 44774. (10.4014/jmb.1607.07057).

Gorecki, S.; Nesslany, F.; Hubé, D.; Mullot, J.-U.; Vasseur, P.; Marchioni, E.; Camel, V.; Noël, L.; Le Bizec, B.; Guérin, T.; Feidt, C.; Archer, X.; Mahe, A.; Rivière, G.
Human health risks related to the consumption of foodstuffs of plant and animal origin produced on a site polluted by chemical munitions of the First World War
Science of the Total Environment, 2017, 599, 314-323. (10.1016/j.scitotenv.2017.04.213).

Lajili, S.; Azouaou, S. A.; Turki, M.; Muller, C. D.; Bouraoui, A.
Anti-inflammatory, analgesic activities and gastro-protective effects of the phenolic contents of the red alga, Laurencia obtusa.
European Journal of Integrative Medicine , 2016, 8(3), 298Ð306. (10.1016/j.eujim.2015.12.006).

Note, O.; Azouaou, S. A.; Simo, L.; Antheaume, C.; Guillaume, D.; Pegnyemb, D.; Muller, C.; Lobstein, A.
Phenotype-specific apoptosis induced by three new triterpenoid saponins from Albizia glaberrima (Schumach. & Thonn.) Benth.
Fitoterapia, 2016, 109, 80-86. (10.1016/j.fitote.2015.12.012).

Hammi, I.; Delalande, F.; Belkhou, R.; Marchioni, E.; Cianférani, S.; Ennahar, S.
Maltaricin CPN, a new class IIa bacteriocin produced by Carnobacterium maltaromaticum CPN isolated from mould-ripened cheese
Journal of Applied Microbiology, 2016, 121(5), 1268-1274. (10.1111/jam.13248).

Zhao, M.; Arau Jo, M. M.; Dal, S.; Sigrist, S.; Bergaentzle, M.; Ramanitrahasimbola, D.; Andrianjara, C.; Marchioni, E.
Development and validation of a selective and effective pressurized liquid extraction followed by liquid chromatography-mass spectrometry method for the determination of fructosazine analogues in the ammonia treated extract of Eugenia jambolana Lamarck seeds
Journal of Chromatography A, 2016, 1473, 66-75. (10.1016/j.chroma.2016.10.035).

Gutierrez-Cepeda, A.; Fernandez, J. J.; Norte, M.; Lopez-Rodriguez, M.; Brito, I.; Muller, C. D.; Souto, M. L.
Additional Insights into the Obtusallene Family: Components of Laurencia marilzae
Journal of Natural Products, 2016, 79(4), 1184Ð1188. (10.1021/acs.jnatprod.5b01080).

Nabergoj, D.; Vrbek, S.; Zidar, N.; Toma_i_, T.; Kikelj, D.; Ma_i_, L.P.; Muller C.D. :
Synthetic analogues of marine alkaloid clathrodin differently induce phosphatidylserine exposure in monocytic cancer cells then in cancer stem cell lines.
MedChemComm, 2016, 8, 1546-1554. (10.1039/C6MD00163G).

Filipovic, N. R.; Bjelogrlic, S.; Portalone, G.; Pelliccia, S.; Silvestri, R.; Klisuric, O.; Sencanski, M.; Stankovic, D.; Todorovic, T. R.; Muller, C. D.
Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines
Medchemcomm, 2016, 7(8), 1604-1616. (10.1039/c6md00199h).

Lajili, S.; Deghrigue, M.; Bel Haj Amor, H.; Muller, C. D.; Bouraoui, A.
In vitro immunomodulatory activity and in vivo anti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red alga Laurencia obtusa.
Pharmaceutical Biology, 2016, 54(11), 2486Ð2495. (10.3109/13880209.2016.1160937).

Note, O. P.; Simo, L. M.; Mbing, J. N.; Guillaume, D.; Azouaou S. A.; Muller, C. D.; Pegnyemb, D. E.; Lobstein, A.
Two new triterpenoid saponins from the roots of Albizia zygia (DC.) J.F. Macbr.
Phytochemistry Letters, 2016, 18, 128-135. (10.1016/j.phytol.2016.09.010).

Tsoukalas, M.; Muller, C. D.; Lobstein, A.; Urbain, A.
Pregnane Glycosides from Cynanchum marnierianum Stimulate GLP-1 Secretion in STC-1 Cells
Planta Medica, 2016, 82(11-12), 992-999. (10.1055/s-0042-107675).

Filipovic, N. R.; Bjelogrlic, S.; Todorovic, T. R.; Blagojevic, V. A.; Muller, C. D.; Marinkovic, A.; Vujcic, M.; Janovic, B.; Malesevic, A. S.; Begovic, N.; Sencanski, M.; Minic, D. M.
Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines
RSC Advances, 2016, 6(110), 108726-108740. (10.1039/c6ra24604d).

Hagemann, M.H.; Bogner, K.; Marchioni, E.; Braun, S.
Chances for dry-hopped non-alcoholic beverages? Part 1: Concept and market prospects
BrewingScience, 2016, 69, 50-55. ().

Munoz, M. D. C.; Benomar, N.; Ennahar, S.; Horvatovich, P.; Lerma, L. L.; Knapp, C. W.; Galvez, A.; Abriouel, H.
Comparative proteomic analysis of a potentially probiotic Lactobacillus pentosus MP-10 for the identification of key proteins involved in antibiotic resistance and biocide tolerance
International Journal of Food Microbiology, 2016, 222, 42217. (10.1016/j.ijfoodmicro.2016.01.012).

Chebbah, Kaoutar; Marchioni, Eric; Sarri, Djamel; Menad, Ahmed; Mekkiou, Ratiba; Seghiri, Ramdane; Boumaza, Ouahiba; Benayache, Samir; Benayache, Fadila
HPLC-UV profile of Genista ulicina Spach. (Fabaceae) extracts and in vitro antioxidant activity
International Journal of Phytomedicine, 2016, 8(3), 398-403. (10.5138/09750185.1863).

Elshaflu, H.; Bjelogrlic, S.; Muller, C. D.; Todorovic, T. R.; Rodic, M.; Marinkovic, A.; Filipovic, N. R.
Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models
Journal of Coordination Chemistry, 2016, 69(22), 3354-3366. (10.1080/00958972.2016.1232404).

Jimenez-Quero, A.; Pollet, E.; Zhao, M.; Marchioni, E.; Averous, L.; Phalip, V.
Itaconic and Fumaric Acid Production from Biomass Hydrolysates by Aspergillus Strains
Journal of Microbiology and Biotechnology, 2016, 26(9), 1557-1565. (10.4014/jmb.1603.03073).

Fatiany, P. R.; Fiatoa, B.; Raoelson, G.; Randrianirina, A. O.; Randriantsoa, A.; Andrianjara, C.; Zhao, M.; Marchioni, E.; Robijaona, B.; Solofoniaina, M.; Kotote, N. N.
Vasodilator effects of Cymbopogon pruinosus (Poaceae) from Madagascar on isolated rat thoracic aorta and structural elucidation of its two bioactive compounds.
Journal of Pharmacognosy and Phytochemistry , 2016, 5, 46-55. ().

Lozano, I.; Van der Werf, R.; Bietiger, W.; Seyfritz, E.; Peronet, C.; Pinget, M.; Jeandidier, N.; Maillard, E.; Marchioni, E.; Sigrist, S.; Dal, S.
High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications
Nutrition & Metabolism, 2016, 13, 15. (10.1186/s12986-016-0074-1).

Jacques, S. A.; Leriche, G.; Mosser, M.; Nothisen, M.; Muller, C. D.; Remy, J. S.; Wagner, A.
From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: a rational approach towards improved cleavable linkers for biospecific endosomal release.
Organic and Biomolecular Chemistry, 2016, 14(21), 4794Ð4803. (10.1039/c6ob00846a).

Bozic, A.; Marinkovic, A.; Bjelogrlic, S.; Todorovic, T. R.; Cvijetic, I. N.; Novakovic, I.; Muller, C.D.; Filipovic, N.R.
Quinoline based mono- and bis-(thio) carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models
RSC Advances, 2016, 6(106), 104763-104781. (10.1039/c6ra23940d    ).