L’équipe de Synthèse pour l’Analyse s’intéresse à la synthèse de nouvelles molécules, complexes et/ou assemblages supramoléculaires et nanoparticules et à leurs applications. Notre expertise concerne plus particulièrement la détection, l’analyse et l’imagerie médicale.
Nos activités s’organisent autour des objets d’étude suivants :
- les ligands macrocycliques et leurs complexes
- les assemblages supramoléculaires et supra-nanoparticulaires hybrides
Et autour des axes de recherches suivants :
- la conversion photonique et en particulier la conversion photonique ascendante
- la détection et quantification d’analytes par spectroscopie de luminescence
- l’imagerie nucléaire : Tomographie à Emission de Positrons et Imagerie par Résonance Magnétique
- la synthèse et l’étude de noyaux super-lourds
Responsable scientifique : Loïc CHARBONNIERE (liste de publications)
Membres de l’équipe SynPA
Publications récentes
↘️ Voir la liste
2023
Moskalevska, I.; Faure, V.; Haye, L.; Mercey-Ressejac, M.; Dey, A.K.; Chovelon, B.; Soro, K.; Charbonnière, L.J.; Reisch, A.; Klymchenko, A.S.; Marche, P.N.; Coll, J.L.; Macek Jilkova, S.; le Guével, Intracellular accumulation and immunological response of NIR-II polymeric nanoparticles, X. Int. J. Pharm. 2023, 630, 122439.
S. K. Kuppusamy, E. Moreno-Pineda, A. M. Nonat, B. Heinrich, L. Karmazin, L.J. Charbonnière, M. Ruben, Binuclear lanthanide complexes based on 4-Picoline-N-oxide: from sensitised luminescence to single-molecule magnet characteristics, Cryst. Growth. Des. 2023, 23, 1084. B., M. De Los Ángeles Ramírez, S. Furgiuele, F. Journe, C. Cheignon, L. Charbonnière, C. Henoumont, C. Kiefer, D. Mertz, C. Affolter-Zbaraszczuk, F. Meyer, S. Saussez, S. Laurent, M. Tasso, S. Bégin-Colin, Bioconjugation studies of an EGF-R targeting ligand on dendronized iron oxide nanoparticles to target head and neck cancer cells , Int. J. Pharm. 2023, 635, 122654
Xie, C.; Wu, Y.; Chau, H.F.; Zhang, T. Wong, C.T.; Yeung, Y.-H.; Lam, P.L.; Bünzli, J.-C.G.; Charbonnière, L.J.; Law, G.L.; Wong, K.L., Multi-modal Visualization of Bioorthogonal Systems by Off-On Luminescence and Enhanced Magnetic Resonance Imaging, Adv. Opt. Mat. 2023, 2203057.
Ndiaye, D.; Sy, M.; Thor, W.; Charbonnière, L.J.; Nonat, A.M.; Tóth, E., Structural variations in carboxylated bispidine ligands: influence of positional isomerism and rigidity on the conformation, stability, inertness and relaxivity of their Mn2+ complexes, Chem. Eur. J. 2023, e202301880.
Harriswangler, C.; Lucio-Martínez, F.; Godec, L.; Soro, K.L.; Fernández-Fariña, S.; Valencia, L.; Rodríguez-Rodríguez, A.; Esteban-Gómez, D.; Charbonnière, L.J.; Platas Iglesias, C., Effect of magnetic anisotropy on the 1H NMR paramagnetic shifts and relaxation rates of small dysprosium(III) complexes, Inorg. Chem. 2023, 62 (35), 14326–14338.
Cheignon, C.; Collin, F.; Sabater, L.; Hureau, C. Oxidative Damages on the Alzheimer’s Related-Aβ peptide Alters Its Ability to Assemble. Antioxidants 2023, 12 (2), 472.
Haye, L.; Fayad, N.; Knighton, R.C.; Combes, A.; Klymchenko, A.; Gallavardin, T.; Hildebrandt, N.; Charbonnière, L.J.; Reisch, A., Near-Infrared FRET Luminescence in Rhenium Complex and Dye Co-Loaded Polymer Nanoparticles, to be published in Adv. Mater. Tech. 2023, 2301016.
Thomas, E.; Mathieu, C.; Moreno-Gaona, P.; Mittelheisser, V.; Lux, F.; Tillement, O.; Pivot, X.; Ghoroghchian, P. P.; Detappe, A., Anti-BCMA Immuno-NanoPET Radiotracers for Improved Detection of Multiple Myeloma. Adv Healthc Mater 2022, 11 (2), e2101565.
Mittelheisser, V.; Coliat, P.; Moeglin, E.; Goepp, L.; Goetz, J. G.; Charbonniere, L. J.; Pivot, X.; Detappe, A., Optimal Physicochemical Properties of Antibody-Nanoparticle Conjugates for Improved Tumor Targeting. Adv Mater 2022, 34 (24), e2110305.
Desligniere, E.; Diemer, H.; Erb, S.; Coliat, P.; Pivot, X.; Detappe, A.; Hernandez-Alba, O.; Cianferani, S., A Combination of Native LC-MS Approaches for the Comprehensive Characterization of the Antibody-Drug Conjugate Trastuzumab Deruxtecan. Front Biosci (Landmark Ed) 2022, 27 (10), 290.
Diringer, M. C.; Coliat, P.; Mathieu, C.; Laurent, N.; Mura, C.; Banerjee, M.; Zhu, C.; Grabowska, A.; Ritchie, A.; Clarke, P.; Bernard, A.; Vit, C.; Burckel, H.; Noel, G.; Harvey, P.; Pivot, X.; Detappe, A., Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects. Small 2023, 19 (12), e2205961.
Detappe, A.; Nguyen, H. V.; Jiang, Y.; Agius, M. P.; Wang, W.; Mathieu, C.; Su, N. K.; Kristufek, S. L.; Lundberg, D. J.; Bhagchandani, S.; Ghobrial, I. M.; Ghoroghchian, P. P.; Johnson, J. A., Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma. Nat Nanotechnol 2023, 18 (2), 184-192.
Cui, G.; Botuyan, M. V.; Drane, P.; Hu, Q.; Bragantini, B.; Thompson, J. R.; Schuller, D. J.; Detappe, A.; Perfetti, M. T.; James, L. I.; Frye, S. V.; Chowdhury, D.; Mer, G., An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nat Commun 2023, 14 (1), 6091.
Carmès, L.; Banerjee, M.; Coliat, P.; Harlepp, S.; Pivot, X.; Tillement, O.; Lux, F.; Detappe, A., Toward Clinical Transfer of Tumor-Targeted Ultrasmall Inorganic Nanoparticles. Adv Therapeutics 2023, 6, 2300019
2022
Thomas, E.; Mathieu, C.; Moreno-Gaona, P.; Mittelheisser, V.; Lux, F.; Tillement, O.; Pivot, X.; Ghoroghchian, P. P.; Detappe, A., Anti-BCMA Immuno-NanoPET Radiotracers for Improved Detection of Multiple Myeloma. Adv Healthc Mater 2022, 11 (2), e2101565.
Mittelheisser, V.; Coliat, P.; Moeglin, E.; Goepp, L.; Goetz, J. G.; Charbonniere, L. J.; Pivot, X.; Detappe, A., Optimal Physicochemical Properties of Antibody-Nanoparticle Conjugates for Improved Tumor Targeting. Adv Mater 2022, 34 (24), e2110305.
Desligniere, E.; Diemer, H.; Erb, S.; Coliat, P.; Pivot, X.; Detappe, A.; Hernandez-Alba, O.; Cianferani, S., A Combination of Native LC-MS Approaches for the Comprehensive Characterization of the Antibody-Drug Conjugate Trastuzumab Deruxtecan. Front Biosci (Landmark Ed) 2022, 27 (10), 290.
Exinger, J.; Hartard, ; Lafferrière, F.; Fenninger, C.; Charbonnière, L.J.; Jeulin, H., Evaluation of a new Lateral Flow Immunoassay method Poly-DTech SARS-CoV-2 IgM/IgG, Jap. J. Infect. Diseases 2022 doi :10.7883/yoken.JJID.2021.273.
Mittelheisser, V.; Coliat, P.; Goepp, L.; Goetz, J.G.; Cox, D.J.; Charbonnière, L.J.; Pivot, X.; Detappe, A., Optimal physicochemical properties of antibody-nanoparticle conjugates for improved tumor targeting, Adv. Mater. 2022. 2110305. DOI: 10.1002/adma.202110305.
Knighton, R.; Soro, L.K.; Thor, W.; Strub, J.-M.; Cianférani, S.; Mély, Y.; Lenertz, M.; Wong, K.L.; Platas-Iglesias, C.; Przybilla, F.; Charbonnière, L.J., Upconversion in a d-f [RuYb3] Supramolecular Assembly, J. Am. Chem. Soc. 2022, 144, 13356-13365.
M. Sy, N. Daouda, I. da Silva, S. Lacerda, L. J. Charbonnière*, E. Toth*, A. M. Nonat*, 55/52Mn2+ Complexes with a Bispidine-Phosphonate Ligand: High Kinetic Inertness for Imaging Applications,
Inorg . Chem., 2022, 61(34), 13421-13432.
Cheignon, C.; Kassir, A.A.; Soro, L.K.; Charbonnière, L.J., Dye sensitized lanthanide containing nanoparticles for luminescence based applications, Nanoscale, 2022, 14, 13915-13949.
Soro, K.L.; Knighton, R.C.; Avecilla, F.; Thor, W.; Przybilla, F.; Jeannin, O.; Esteban-Gomez, D.; Platas-Iglesias, C.; Charbonnière, L.J., Solution-state Cooperative Luminescence Upconversion in Molecular Ytterbium Dimers, Adv. Opt. Mater. 2022, 2202307.
2021
Les bispidines et les ions métalliques : un mariage qui dure A. M. Nonat, Actualité Chimique, 2021 (459), 12-19.
Mertes, P. M.; Collange, O.; Coliat, P.; Banerjee, M.; Diringer, M. C.; Roche, A.; Delabranche, X.; Chaban, V.; Voegelin, M.; Bernard, A.; Sartori, V.; Laurent, N.; Velten, M.; Dhindsa, N.; Defuria, J.; Kim, G.; Xu, Z. H.; Theodorou, M.; Huang, Z. R.; Khalifa, K.; Geng, B.; Niyikiza, C.; Moyo, V.; Gizzi, P.; Villa, P.; Detappe, A.; Pivot, X., Liposomal encapsulation of trans-crocetin enhances oxygenation in patients with COVID-19-related ARDS receiving mechanical ventilation. J Control Release 2021, 336, 252-261.
Ghoroghi, S.; Mary, B.; Larnicol, A.; Asokan, N.; Klein, A.; Osmani, N.; Busnelli, I.; Delalande, F.; Paul, N.; Halary, S.; Gros, F.; Fouillen, L.; Haeberle, A. M.; Royer, C.; Spiegelhalter, C.; Andre-Gregoire, G.; Mittelheisser, V.; Detappe, A.; Murphy, K.; Timpson, P.; Carapito, R.; Blot-Chabaud, M.; Gavard, J.; Carapito, C.; Vitale, N.; Lefebvre, O.; Goetz, J. G.; Hyenne, V., Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes. Elife 2021, 10.
Demarchi, M.; Coliat, P.; McLendon, K.; Chung Shii Hii, J.; Feyaerts, P.; Ang, F.; Jaison, L.; Deforce, F.; Derde, M. P.; Kim, M. J.; Park, L. S.; Detappe, A.; Pivot, X., TROIKA-1: A double-blind, randomized, parallel group, study aimed to demonstrate the equivalent pharmacokinetic profile of HD201, a potential biosimilar candidate to trastuzumab, versus EU-Herceptin((R)) and US-Herceptin((R)) in healthy male subjects. Pharmacol Res Perspect 2021,9 (4), e00839.
Knighton, R. C.; Soro, L. K.; Francés-Soriano, L.; Rodríguez-Rodríguez, A.; Pilet, G.; Lenertz, M.; Platas-Iglesias, C.; Hildebrandt, N.; Charbonnière, L. J., Cooperative Luminescence and Cooperative Sensitisation Upconversion of Lanthanide Complexes in Solution. Angew. Chem. Int. Ed., accepted manuscript.
Dalvand, P.; Nono, K. N.; Shetty, D.; Benyettou, F.; Asfari, Z.; Platas-Iglesias, C.; Olson, M. A.; Trabolsi, A.; Elhabiri, M. Viologen–Cucurbituril Host/Guest Chemistry – Redox Control of Dimerization versus Inclusion. RSC Adv. 2021, 11 (47), 29543–29554.
M’Hanni, N.; Galai, M.; Ouakki, M.; Touhami, M. E.; Rifi, E. H.; Asfari, Z. Calixarene Molecule as an Effective Inhibitor of Copper Corrosion in 2.0 M H3PO4 and 0.5 M H2SO4 Solutions. International Journal of Corrosion and Scale Inhibition 2021, 10 (3).
Soro, L. K.; Charpentier, C.; Przybilla, F.; Mély, Y.; Nonat, A. M.; Charbonnière, L. J. Yb to Tb Cooperative Upconversion in Supramolecularly Assembled Complexes in a Solution. Chemistry 2021, 3 (3), 1037–1046.
Cheignon, C.; Heurté, M.; Knighton, R.; Kassir, A. A.; Lecointre, A.; Nonat, A.; Boos, A.; Christine, C.; Asfari, Z.; Charbonnière, L. J. Investigation of the Supramolecular Assembly of Luminescent Lanthanide Nanoparticles Surface Functionalized by P-Sulfonato-Calix[4]Arenes with Charged Aromatic Compounds. European Journal of Inorganic Chemistry 2021, 2021 (36), 3761–3770.
Zabierowski, P. W.; Jeannin, O.; Fix, T.; Guillemoles, J.-F.; Charbonnière, L. J.; Nonat, A. M. From Mono- to Polynuclear Coordination Complexes with a 2,2′-Bipyrimidine-4,4′-Dicarboxylate Ligand. Inorganic Chemistry 2021, 60, 8304.
Vaňura, P.; Selucký, P.; Asfari, Z. Towards Selective Separations of Monovalent Cations by Solvent Extraction of Their Calix[4]Crown Complexes in Water-Nitrobenzene Systems. Journal of Molecular Liquids 2021, 336, 116357.
Kumar, K.S., Serrano, D., Nonat, A.M., Heinrich, B., Karmazin, L., Charbonnière, L.J., Goldner, P., Ruben, M., 2021. Optical spin-state polarization in a binuclear europium complex towards molecule-based coherent light-spin interfaces. Nature Communications 12, 2152.
Knighton, R.C., Soro, L.K., Lecointre, A., Pilet, G., Fateeva, A., Pontille, L., Francés-Soriano, L., Hildebrandt, N., Charbonnière, L.J., 2021. Upconversion in molecular hetero-nonanuclear lanthanide complexes in solution. Chem. Commun. 57, 53–56.
Knighton, R.C., Troadec, T., Mazan, V., Le Saec, P., Marionneau-Lambot, S., Le Bihan, T., Saffon-Merceron, N., Le Bris, N., Cherel, M., Faivre-Chauvet, A., Elhabiri, M., Charbonniere, L.J., Tripier, R., 2021b. Cyclam-Based Chelators Bearing Phosphonated Pyridine Pendants for Cu-64-PET Imaging: Synthesis, Physicochemical Studies, Radiolabeling, and Bioimaging. Inorg. Chem. 60, 2634–2648.
Ye, G., Roques, J., Solari, P.-L., Den Auwer, C., Jeanson, A., Brandel, J., Charbonniere, L.J., Wu, W., Simoni, E., 2021. Structural and Thermodynamics Studies on Polyaminophosphonate Ligands for Uranyl Decorporation. Inorg. Chem. 60, 2149–2159.
2020
Cardoso, D.S.M., Charbonniere, L., Charpentier, C., Cifliku, V., Goetz, J., Hildebrandt, N., Nonat, A., Wong, K.-L., 2020. Nanoparticules De Lanthanide Luminescentes Ultra Brillantes Comprenant Du Terbium Et Ayant Une Durée De Vie Plus Longue À L’état Excité. EP3591024A1.
Charpentier, C., Cifliku, V., Goetz, J., Nonat, A., Cheignon, C., Cardoso Dos Santos, M., Francés-Soriano, L., Wong, K.-L., Charbonnière, L.J., Hildebrandt, N., 2020a. Ultrabright Terbium Nanoparticles for FRET Biosensing and in Situ Imaging of Epidermal Growth Factor Receptors. Chem. Eur. J. 26, 14602–14611.
Charpentier, C., Salaam, J., Nonat, A., Carniato, F., Jeannin, O., Brandariz, I., Esteban-Gomez, D., Platas-Iglesias, C., Charbonnière, L.J., Botta, M., 2020b. pH-Dependent Hydration Change in a Gd-Based MRI Contrast Agent with a Phosphonated Ligand. Chemistry – A European Journal 26, 5407–5418.
Knighton, R.C., Soro, L.K., Troadec, T., Mazan, V., Nonat, A.M., Elhabiri, M., Saffon-Merceron, N., Djenad, S., Tripier, R., Charbonniere, L.J., 2020. Formation of Heteropolynuclear Lanthanide Complexes Using Macrocyclic Phosphonated Cyclam-Based Ligands. Inorg. Chem. 59, 10311–10327.
L’Her, M., Atoini, Y., Fouchet, J., Heinrich, B., Del-Giudice, N., Scrafton, E., Bordes, E., Karmazin, L., Charbonniere, L., De Cola, L., Douce, L., 2020. Luminescent imidazolium-naphthalene salts in liquid and solid states (vol 43, pg 12529, 2019). New J. Chem. 44, 2669–2669.
Mittelheisser, V., Banerjee, M., Pivot, X., Charbonniere, L.J., Goetz, J., Detappe, A., 2020. Leveraging Immunotherapy with Nanomedicine. Adv. Therap. 3, 2000134.
Molloy, J.K., Nonat, A.M., O’Brien, J.E., Brougham, D.F., Gunnlaugsson, T., 2020. Self-assembled Ln(III) cyclen-based micelles and AuNPs conjugates as candidates for luminescent and magnetic resonance imaging (MRI) agents. Supramol. Chem. 32, 373–382.
Ndiaye, D., Sy, M., Pallier, A., Même, S., Silva, I. de, Lacerda, S., Nonat, A.M., Charbonnière, L.J., Tóth, É., 2020. Unprecedented Kinetic Inertness for a Mn2+-Bispidine Chelate: A Novel Structural Entry for Mn2+-Based Imaging Agents. Angewandte Chemie International Edition 59, 11958–11963.
Nonat, A.M., Charbonnière, L.J., 2020. Upconversion of light with molecular and supramolecular lanthanide complexes. Coordination Chemistry Reviews 409, 213192.
Price, T.W., Yap, S.Y., Gillet, R., Savoie, H., Charbonnière, L.J., Boyle, R.W., Nonat, A.M., Stasiuk, G.J., 2020. Evaluation of a Bispidine-Based Chelator for Gallium-68 and of the Porphyrin Conjugate as PET/PDT Theranostic Agent. Chemistry – A European Journal 26, 7602–7608.
Novikov, K.V., Kozulin, E.M., Knyazheva, G.N., Itkis, I.M., Karpov, A.V., Itkis, M.G., Diatlov, I.N., Cheralu, M., Gall, B., Asfari, Z., Kozulina, N.I., Kumar, D., Pchelintsev, I.V., Loginov, V.N., Bondarchenko, A.E., Singh, P.P., Vorobiev, I.V., Heinz, S., Trzaska, W.H., Vardaci, E., Tortorelli, N., Borcea, C., Harca, I., 2020. Formation and Decay of the Composite System Z = 120 in Reactions with Heavy Ions at Energies Near the Coulomb Barrier. Bull.Russ.Acad.Sci.Phys. 84, 495–499.
Yeremin, A., Lopes-Martens, A., Hauschild, K., Popeko, A., Malyshev, O., Chepigin, V., Svirikhin, A., Isaev, A., Popov, Yu., Chelnokov, M., Kuznetsova, A., Dorvaux, O., Gall, B., Asfari, Z., Tezekbaeva, M., Piot, J., Antalic, S., 2020. Velocity filter SHELS: Performance and experimental results. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 463, 219–220.
M’hanni, N., Galai, M., Ouakki, M., Touhami, M., Rifi, E., Asfari, Z., 2020. Comparative study of the copper inhibition of two [H4L]calixarenic molecules in sulfuric acid medium. International Journal of Corrosion and Scale Inhibition 9, 1037–1048.
M’hanni, N., Galai, M., Anik, T., Touhami, M., Rifi, E.H., Asfari, Z., 2020. Investigation of Calix[4]arene Molecule on Electroless Ni-P Alloy on Carbon Steel Substrate and Evaluation of its Corrosion Resistance in 3% NaCl. Asian Journal of Chemistry 32, 1384–1392
Shetty, D., Jahović, I., Skorjanc, T., Erkal, T.S., Ali, L., Raya, J., Asfari, Z., Olson, M.A., Kirmizialtin, S., Yazaydin, A.O., Trabolsi, A., 2020. Rapid and Efficient Removal of Perfluorooctanoic Acid from Water with Fluorine-Rich Calixarene-Based Porous Polymers. ACS Appl. Mater. Interfaces 12, 43160–43166.
Shetty, D., Boutros, S., Skorjanc, T., Garai, B., Asfari, Z., Raya, J., Trabolsi, A., 2020. Fast and efficient removal of paraquat in water by porous polycalix[n]arenes (n = 4, 6, and 8). J. Mater. Chem. A 8, 13942–13945.